Amoxicillin capsules are generally recommended to be taken 1 hour after meals to minimize the irritation of the drug to the gastrointestinal tract. Amoxicillin is a penicillin antibiotic, belonging to the β-lactam class of antibiotics, which can play a bactericidal role by binding to bacterial penicillin-binding proteins (pbps) and inhibiting bacterial cell wall synthesis. Amoxicillin is commonly used clinically to treat infections of the respiratory tract, genitourinary tract, skin and other tissues caused by infections with sensitive bacteria such as Streptococcus pneumoniae, Streptococcus haemolyticus, and Escherichia coli, and is also used for eradication therapy of Helicobacter pylori. Amoxicillin may cause adverse reactions such as nausea, diarrhea, vomiting, rash, anemia, etc. It is irritating to the gastrointestinal tract, therefore, it is generally recommended to take it 1 hour after meals to reduce the irritation of the drug to the gastrointestinal tract. Amoxicillin is recommended to consult a doctor in advance when using it, and take it strictly according to the doctor’s instructions, not self-medication, so as not to delay or even aggravate the condition.