Splenectomy may lead to decreased immunity. The spleen is the source of a portion of the antibodies produced by the body and is the main site of immunoglobulin M production. Immunoglobulin M has powerful bactericidal, complement-activating, immunomodulatory and agglutinating effects. After splenectomy, immunoglobulin M production decreases, thus the body’s immunity will be reduced and it will be prone to infections, such as respiratory tract infections and intestinal infections. However, the spleen is not the only immune organ in the body, and the body’s immunity can be restored to a certain extent for a period of time after surgery. After splenectomy, attention should be paid to strengthening the body’s immunity, such as appropriate exercise. After splenectomy, if there is any physical discomfort, go to a regular hospital in time, and the doctor will judge the cause of the disease according to the condition, determine whether it is caused by splenectomy, and then give the correct treatment for the cause of the disease.