Factor 8 in the blood is the activity of coagulation factor VIII, which has a normal value of 78 to 128%.
Coagulation factor VIII is synthesized by the liver and serves as a cofactor to the endogenous coagulation factors that enable the clotting process to proceed. Both deficiencies and increases in coagulation factor VIII affect the function of the body.
Hemophilia A develops a deficiency of coagulation factor VIII due to a congenital genetic defect. Acquired decreased activity of coagulation factor VIII is most often caused by autoimmune diseases, malignant tumors, infections, and other diseases. If you suffer from liver diseases such as hepatitis, cirrhosis, or liver cancer, it can lead to a decrease in the synthesis of coagulation factor VIII, which in turn leads to clotting dysfunction. There are also some cases of acquired decreased activity of coagulation factor VIII for which the cause is unknown.
In disseminated intravascular coagulation, coagulation factor VIII can be overconsumed, leading to a decrease in quantity.
Increased coagulation factor VIII indicates the presence of thrombotic disorders or hypercoagulability of the blood, such as pulmonary embolism, lower extremity venous thrombosis, hypertensive syndrome of pregnancy, and malignancy.
If coagulation factor VIII is deficient or elevated, it is recommended to go to the hospital in a timely manner for a complete examination to determine the cause of the disease and then give targeted treatment or therapy.