Upper Jiao Fire and Lower Jiao Cold is characterized by the coexistence of upper Jiao heat symptoms such as irritable heat in the chest (agitation and sultriness), sore throat and dry mouth, and lower Jiao cold symptoms such as clear and long urination and coldness in the waist and knees (a feeling of soreness and weakness in the waist and knees). Upper Jiao Fire and Lower Jiao Cold is a mixture of Heat and Cold, i.e., the same patient has both Lower Jiao Cold and Upper Jiao Heat at the same time, which can be manifested as Upper Jiao Heat such as irritable heat in the chest (agitation and sultriness), sore throat, dry mouth, etc., and at the same time, there are signs of Kidney Yang deficiency such as oedema, pallor, clear and long urination, fear of coldness, cold hands and feet, coldness in the waist and knees, and fatigue. Patients who have heat in the upper burner and cold in the lower burner should use medication under the guidance of a doctor to prevent delays in their condition.