Pressing pain in the calf area is divided into physiological pain and pathological pain, of which the pathology includes lower limb soft tissue contusion/sprain, osteoarthritis, lower limb deep vein thrombosis, etc. The treatment methods include massage, acupuncture, medication and surgery. 1. Physiological pain: such as after strenuous exercise, due to excessive accumulation of lactic acid caused by the calf area pressure pain, generally through rest, or massage and other methods can disappear. 2. Pathological pain (1) Lower limb soft tissue contusion/sprain: external medication such as safflower oil can be used, together with oral medication such as piroxicam. (2) Osteoarthritis: medications such as anti-inflammatory and analgesic drugs (e.g., indomethacin, etc.), hormonal drugs (e.g., prednisolone, etc.), and traditional Chinese medicines (e.g., lei gongteng, etc.) can be used. At the same time, acupuncture, massage and acupressure can be used to relieve the symptoms. (3) Lower extremity deep vein thrombosis: first of all, thrombolytic therapy, commonly used drugs such as urokinase. For patients with surgical indications, surgical treatment can be adopted, such as surgical removal of thrombus, saphenous vein diversion grafting and so on. In addition to the above diseases, soft tissue contusion of the calf can also cause pain on pressure in the calf area, which can be treated with physiotherapy and medication (e.g. piroxicam). If the above symptoms occur, it is recommended to go to the hospital to find out the cause of the disease and have regular treatment. All the above medications should be used under the guidance of a doctor or pharmacist, avoid self-medication.