Small blisters around the mouth can be caused by temperature irritation, or viral or bacterial infections. Depending on the cause, blisters can be removed by picking or medication. 1. Temperature stimulation: Eating hot food such as spicy hot pot, hot pot, hot soup, etc., will lead to scalding reaction of the mucous membrane of the lips and small blisters. Small blisters are not recommended to pick, can be used externally with glycerine lotion, etc., to play the role of astringent, pain relief. If the blisters are large, it is necessary to use a sterile syringe to puncture and draw out the blisters, and then use iodine to sterilize, but also can be used externally antibiotic ointment such as mupirocin ointment. 2. Viral infections: common in herpes simplex virus infection, usually appear in clusters of blisters, accompanied by pain. Wet compresses can be applied with cotrimoxazole mouthwash, and antiviral drugs such as ganciclovir, acyclovir and famciclovir can be taken. 3. Bacterial infections: Commonly found in impetigo, which is most common in children, it also manifests itself as small blisters around the lips, which then turn into pustules, break out and ooze out, and crust with honey and yellow scabs. At this time you need to pay attention to local skin care. Pustules unbroken can be used externally with glycerine lotion, pustules should be extracted when larger blisters, pustules broken can be used 1:5000 potassium permanganate solution or 0.5% neomycin solution to wash the wet compresses, and then externally with mupirocin ointment. The small blisters around the mouth continued not to eliminate, to the hospital in a timely manner, a clear diagnosis, symptomatic treatment, drugs need to be used in accordance with medical advice.