Hepatic coma refers to hepatic encephalopathy, which is caused by liver disease, abnormal portal-corporeal shunting, and other metabolic abnormalities. Hepatic encephalopathy is a neurologic or psychiatric abnormality associated with central nervous system dysfunction caused by severe liver disease. Acute liver failure and cirrhosis are the main causes of hepatic encephalopathy, as are abnormal portal-body circulation shunting and metabolic abnormalities. Hepatic encephalopathy should strictly limit protein intake, and lactulose can be used to acidify the intestines and reduce the absorption of ammonia, in addition, it can also be treated by liver transplantation or artificial liver. Daily rest should be paid attention to, avoid strenuous exercise and overwork, focus on monitoring the patient’s thinking and cognitive situation, and medication please follow the doctor’s instructions.