Neoguan is an inflammatory disease of the lungs caused by a novel coronavirus. Treatment includes general treatment, antiviral treatment, immunotherapy, anticoagulation, prone position treatment, psychotherapy, supportive therapy and Chinese medicine. 1. General treatment: bed rest, strengthening nutritional support, monitoring vital signs, regular rechecking of blood routine, biochemical indexes, blood gases and chest CT, etc., avoiding blind use of antibacterial drugs. 2. Antiviral therapy: patients with new coronavirus pneumonia usually use ritonavir tablets, monoclonal antibodies, human immunoglobulin, recovery plasma of recovered patients and other antiviral therapy. 3. Immunotherapy: including glucocorticoids, interleukin 6 inhibitor tolizumab and so on. 4. Anticoagulation therapy: low molecular heparin anticoagulation can be given to critically ill patients without contraindications. 5. Prone position treatment: patients with high risk factors for severe disease and rapid progression of ordinary, heavy and critical patients can be given standardized prone position treatment for not less than 12 hours a day. 6. Psychological intervention: for those who are nervous and anxious, psychological counseling or medication should be strengthened. 7. Supportive treatment: mainly including nasal catheter or mask oxygen, transnasal high-flow oxygen therapy or non-invasive ventilation, invasive mechanical ventilation, extracorporeal membrane pulmonary oxygenation, fluid resuscitation and renal replacement therapy. 8. Chinese medicine treatment: including Lianhua Qingdian capsule, Jinhua Qingdian granule, Xuanlong septicemia granule, Haibijie injection, fever virus injection, etc. Confirmed diagnosis of new coronavirus pneumonia patients need to be isolated, standardized treatment. Tips] In this article, “new coronavirus pneumonia” and “new coronavirus pneumonia” have been renamed to “new coronavirus infection” on December 26, 2022, as announced by the National Health Commission.