Coughing after lung nodule surgery should choose different drugs according to different causes, for example, carboxymetholestane oral solution for postoperative reaction, penicillin for infection and so on. 1. Postoperative reaction: the most common reason for coughing after lung nodule surgery is postoperative reaction. Generally, there will be coughing phenomenon after lung nodule surgery because the resection edge part of the lung is particularly sensitive to the change of air pressure, temperature and other factors, which causes coughing symptoms. You can take oral carboxymethyl stannum oral solution and other cough medication, if the effect of oral medication is not good, you can choose nebulized inhalation treatment. 2. Infection: patients with weakened immune function after lung nodule surgery may suffer from respiratory tract inflammation caused by infection, such as bronchitis and other symptoms, which can also cause coughing, you can choose penicillin, cephalosporin and other antibiotics for treatment. All of the above drugs should be used under the guidance of a doctor. Coughing after lung nodule surgery should be followed up in time, and the doctor should choose the appropriate medicine according to the examination results.