Pain in the buttocks and thighs in the early hours of every morning may be caused by lumbar disc herniation, pyriformis syndrome, fasciitis, ankylosing spondylitis and other causes. 1. Lumbar disc herniation: it can compress the nerve root, which leads to radioactive pain in the buttocks and legs, and this pain is particularly obvious in the buttocks and the back of the thighs. You can go to the hospital for lumbar spine CT examination or nuclear magnetic. You can also take oral medication such as celecoxib and ibuprofen extended-release capsules. 2. Piriformis syndrome: the piriformis muscle compresses the sciatic nerve, and the patient will have pain at the back of the buttocks, and some patients will have pain at the root of the thighs, and there will be pain at the same time in front and back. You can take oral lidocaine, ibuprofen, indomethacin and other drugs, but also appropriate physiotherapy, massage. Avoid sitting for a long time, and pay attention to keep warm. 3. Lumbar myofasciitis: Lumbar myofasciitis may cause lumbar pain, and reflexively cause hip and thigh pain symptoms. Usually avoid overwork, pay attention to keep warm, can also be used to bake electric physiotherapy method to relieve the symptoms. 4. Ankylosing spondylitis: this is a chronic rheumatic immune disease, mainly involving the sacroiliac joints, spine and with varying degrees of extra-articular manifestations. Usually slow onset and insidious, early is lumbosacral pain, morning stiffness symptoms, to diagnose ankylosing spondylitis need to go to the hospital to improve the HLA-B27 test and examination and by the specialist combined with physical examination, medical history to determine. Every day in the early hours of the morning buttocks and thighs are painful should be timely medical treatment, under the guidance of the doctor examination and treatment.