A cold with a fever of 38.5 ℃ and then fever again may be related to the lack of antiviral treatment, complications or other diseases caused by the need to address the specific causes of treatment. 1. No antiviral treatment: the common cold is caused by viral infection, there can be fever and other symptoms, the general symptomatic use of acetaminophen and other antipyretic analgesic drugs to reduce fever, the disease can be self-cured. However, influenza has high fever and other symptoms, only antipyretic and symptomatic treatment can not control viral replication, which may lead to recurrent fever, and need to use antiviral drugs such as oseltamivir to control the condition. 2. Complications: If the resistance is low, complications such as bronchopneumonia may occur, which may cause recurrent fever and require active anti-infective treatment. If secondary bacterial infection, levofloxacin, cefixime and other active anti-infective treatment can be used. 3. Other diseases: such as malignant tumors or autoimmune diseases can also cause recurrent fever, and need to be treated for the corresponding causes. Recurrent fever can be caused by a variety of diseases, if the symptoms do not improve or aggravate, it is recommended to consult a doctor in a timely manner, under the guidance of the doctor to carry out relevant examinations, to determine the cause of the disease, and then in accordance with the doctor’s instructions for treatment.