Leukemia nosebleeds are not specific and can be unilateral or bilateral. Leukemia is a kind of malignant clonal disease of hematopoietic stem progenitor cells, leukemia cell proliferation is out of control, differentiation is impaired, apoptosis is blocked, in the bone marrow and other hematopoietic tissues, leukemia cells proliferate and accumulate in large quantities, and the normal hematopoiesis is inhibited and infiltrates other organs and tissues. Nearly 40% of the patients may show bleeding in the early stage, such as nosebleed, gum bleeding and so on. Bleeding is not specific and can occur in all parts of the body. Nosebleeds can be unilateral or bilateral, and the bleeding time may be long, not easy to stop bleeding and easy to repeat. Leukemia nosebleeds should be actively stop bleeding and actively standardized treatment of leukemia, regular review, and strive for early recovery.