Generally, a healthy and normal person will not have thickening of liver parenchyma echoes, which usually indicates liver lesions. Normal liver echoes should be fine and even, when ultrasound examination found that the echoes are thickened, we need to be alert to liver injury. If there is a history of hepatitis and the physical examination reveals thickening of the liver parenchyma echogenicity, it may be a sign of continued progression of liver disease, hepatic fibrosis and cirrhosis. It is recommended to further check the liver function, if necessary, also can be carried out hepatitis B five, hepatitis C antibody test. If a normal person has thickened echoes, it may be the appearance of fatty liver changes. Especially people who are obese, have irregular diet and like to eat greasy food need to pay more attention to the fatty liver changes. Lipid tests are recommended for a definitive diagnosis. If thickening of liver parenchymal echoes is found, it is recommended to actively consult the doctor and improve relevant examinations to clarify the diagnosis and standardize the treatment.