Common causes of high immunoglobulin E include hypersensitivity disorders and infectious diseases. Immunoglobulin E is mainly produced by plasma cells in the lamina propria of the mucous membranes of the respiratory and digestive tracts, and is found in extremely low levels in the blood of normal people, where it is associated with type I allergic reactions. When the body undergoes hypersensitivity diseases, such as allergic rhinitis, asthma, chronic urticaria, etc., as well as infectious diseases such as parasitic infections, acute and chronic hepatitis, bronchopulmonary aspergillosis, etc., immune reactions can be induced and elevated immunoglobulin E can occur. Therefore, it is recommended that patients with elevated immunoglobulin E should consult a doctor in time to determine the cause of the disease by combining the symptoms and other test results, and then target treatment under the guidance of the doctor.