Pheochromocytoma occurring in the pancreas is called pancreatic paraganglioma. Surgical resection is the first choice for the treatment of pancreatic paraganglioma, and it can still be operated again after recurrence and metastasis. Most of the pheochromocytomas are located in adrenal glands, and the pheochromocytomas occurring outside the adrenal glands are called paragangliomas. Paragangliomas are benign and malignant, and it is difficult to judge their benign and malignant by histological examination, and they are generally judged to be benign and malignant by metastasis. The hazards of paraganglioma on human body include the structural damage or dysfunction of the primary site or other organs caused by tumor growth and metastasis, as well as the effects of neuroendocrine substances released by the tumor on the body. Paraganglioma is not sensitive to radiotherapy, therefore, early surgical treatment should be carried out after finding lesions and determining the diagnosis, and thorough and complete resection of the tumor during surgery is the key to prevent recurrence.