You should not drink alcohol while taking fever-reducing medications. In fact, you should not drink alcohol while taking most medications. Antipyretics are also known as antipyretic and anti-inflammatory drugs, which require enzymes for their metabolism in the body. Alcohol metabolism also needs enzymes, antipyretic drugs and alcohol taken at the same time, will interfere with each other enzyme metabolism process. 1. Alcohol interferes with the metabolism of antipyretics: Alcohol robs the metabolizing enzymes of antipyretics, leading to a decrease in the metabolism of antipyretics, an enhancement of their efficacy, and an increase in the incidence of adverse drug reactions, such as gastrointestinal discomfort, nausea and vomiting, ulcers, bleeding, etc., or causing skin damage, such as photosensitivity, exfoliative dermatitis, etc.. It may also lead to serious consequences such as liver and renal system damage. 2. Antipyretics interfere with alcohol metabolism: antipyretics inhibit the metabolic process of alcohol, leading to the accumulation of acetaldehyde in the body, causing headache, abdominal pain, palpitations, dyspnea and other symptoms, and in severe cases can be life-threatening. In order to be safe, it is recommended to avoid drinking alcohol when taking antipyretic drugs and within 1 to 2 weeks after stopping the drugs, in order to prevent adverse consequences. In addition, alcohol should be avoided when taking most clinical medications.