Quadruple therapy requires the simultaneous administration of one acid-suppressing drug, two antibiotics and a drug to protect the gastric mucosa, and needs to be carried out under the guidance of a specialized physician. Quadruple therapy is a commonly used clinical method of combining drugs, the main effect is to kill Helicobacter pylori. The main method of taking the drug is to take an acid-suppressing drug and two antibiotics and a gastric mucous membrane protector together, generally two weeks a course of treatment, the specific need to refer to the patient’s condition. Generally speaking, the acid-suppressing drugs in the quadruple therapy are mainly proton pump inhibitors, commonly used are omeprazole, pantoprazole, rabeprazole, etc. The two antibiotics are mainly clarithromycin, metronidazole, tetracycline, furazolidone, amoxicillin and levofloxacin, etc., which need to be selected according to the drug-resistant condition and the patient’s specific situation of the liver and renal function, such as combination of drugs; the gastric mucous membrane protection drugs are mainly bismuth. Commonly used bismuth pectin, bismuth potassium citrate and so on. Specific medication should follow the doctor’s instructions. During the medication period, patients should pay attention to the continuous use of drugs to avoid missing doses, so as not to lead to failure of drug therapy. Due to certain risks and contraindications of drug treatment, the use of quadruple therapy should be carried out under the guidance of a professional physician, so as not to lead to adverse consequences.