Cotrimoxazole tablets should not be used to treat toothache. Compound aminophenol alkylamine tablets belong to a kind of compound preparation, which is suitable for the treatment of headache, fever, sore throat, nasal congestion, runny nose, sneezing, limb aches and pains caused by cold and flu. The drug contains acetaminophen with antipyretic and analgesic effects, but the drug acetaminophen 0.25g/tablet, the amount of medicine is low, the effect of the treatment of toothache is not obvious. Generally speaking, pulpitis, gum infection, tooth destruction exposed nerve may cause toothache, patients need to use acetaminophen 0.5g/tablet or anti-inflammatory and analgesic drugs, such as diclofenac sodium, loxoprofen, ibuprofen and other drugs, are able to reduce toothache. In short, the occurrence of toothache, go to the hospital in time to check, find the cause of the disease, the cause of treatment.