Breast cancer brain metastasis can be treated with targeted drugs such as trastuzumab, patuximab, ramorubicin, sunitinib, olaparib, etc. according to the presence of target mutations. Targeted drugs enter the body by specifically selecting the oncogenic site to combine the action, causing tumor cells to die specifically, without affecting the normal tissue cells around the tumor. Different drugs can be used depending on the target mutation. If HER2 positivity is present, treatment with drugs such as trastuzumab and patuximab and lapatinib may be considered. Vascular endothelial growth factor it is a key factor in angiogenesis and the main cause of tumorigenesis, progression, and metastasis, and the targeted drugs for it are ramucirumab, as well as multi-targeted sorafenib and sunitinib. Polyadenosine diphosphate ribose polymerase (PADP-RP) affects the repair of DNA damage, causing accumulation of DNA damage and eventually inducing apoptosis of tumor cells. Triple-negative breast cancer is often caused by defects or mutations in PADP-RP, and targeted drugs for this type of breast cancer include olaparib, and so on. If breast cancer brain metastasis occurs, you need to follow the doctor’s instructions for standardized treatment, do not self-medication.