Thinning and uneven renal parenchyma is usually seen on renal ultrasound, which mostly indicates a sonographic manifestation of renal parenchymal damage, and needs to be considered for the presence of abnormal renal function. Blood tests can be performed to check the levels of creatinine and urea nitrogen, and routine urinalysis can be done to determine whether there are changes in the protein and visible components of the urine. At the same time, patients should be observed for any significant changes in their clinical presentation. For example, in the early morning, edema will be found in loose tissues, especially eyelids and ankles, and this edema is suppressed by acupressure, which will last for a long time and will not be restored, which is a manifestation of impaired renal function. If the type of renal disease is to be determined, renal biopsy is feasible to clarify the diagnosis if necessary. It is recommended that patients with renal parenchymal thinning and unevenness should go to the hospital for timely examination and treatment under the guidance of doctors.