Hydrocortisone overdose has been associated with obesity and secondary osteoporosis, impaired function of the intestinal mucosa, and may be associated with gastric acid hypersecretion and mucosal erosions, leading to upper gastrointestinal bleeding and reflux, nausea and vomiting, acid reflux, heartburn, abdominal distension, abdominal pain, diarrhea, and other clinical symptoms. Hydrocortisone is a short-acting corticosteroid ointment that is less concentrated than other hormone ointments, making its therapeutic effect relatively low. This medicine is mainly used in children or in some sensitive areas, and because of its relatively low concentration, it does not cause skin irritation. The main effects are anti-allergic, anti-inflammatory, anti-itching and elimination of localized inflammation. Hydrocortisone is a hormonal drug, so it should not be taken in excess or for a long period of time. It is recommended to use the drug correctly under the guidance of a doctor to prevent uncomfortable symptoms. Hydrocortisone should not be used in large quantities, and if overdosed, it can cause the clinical side effects mentioned above. Therefore, small amounts of tapering medication and adequate dosage are required. Regular and discretionary dosage reductions and indications for use of the drug are based on the patient’s clinical condition.