Spotting on the tiger’s mouth of the hand may be caused by seborrheic keratosis, café-au-lait spots or post-inflammatory hyperpigmentation. 1. Seborrheic keratosis: Seborrheic keratosis is prevalent in the elderly, and the cause of its formation is related to aging, ultraviolet radiation and other factors. It can be removed by laser, frozen by liquid nitrogen or treated by surgery. 2. Coffee spot: Coffee spot can be seen from birth to childhood, and its formation is related to genetic factors to a certain extent, and some patients may gradually fade with age, and it can be improved by laser in treatment. 3. Post-inflammatory hyperpigmentation: If patients have eczema and other inflammatory skin diseases in the tiger’s mouth area, it may promote the precipitation of melanin, thus forming pigment spots. This kind of pigmentation spot can fade away gradually with the metabolism of human body, and can also be treated by laser or using vitamin C and other drugs. For the hand tiger’s mouth spot patients, it is recommended to go to the regular hospital for examination in a timely manner, under the guidance of a professional doctor for symptomatic treatment.