Chemotherapy is given about 4 weeks after surgery for moderately differentiated carcinoma of the colon T3N1M0, but it should be considered according to the patient’s postoperative recovery as well as physical condition. Colon moderately differentiated adenocarcinoma T3N1M0 suggests that the patient has lymph node metastasis and has a high risk of recurrent metastasis, which should be supplemented with chemotherapy to reduce the probability of recurrent metastasis. The timing of chemotherapy is generally recommended to be about 4 weeks after surgery, when the patient generally recovers well and the tumor load is low, and early chemotherapy, can achieve better efficacy. Postoperative recovery and general physical condition is an important basis for whether chemotherapy can be given, poor recovery and general physical weakness should be adjusted in time, good condition to tolerate chemotherapy. Therefore, the time of postoperative chemotherapy for T3N1M0 moderately differentiated colon cancer should be comprehensively evaluated and reasonably selected.