The pathogenesis of fever is fundamentally different from that of Crohn’s disease, but the symptoms are similar. The symptoms of fever caused by cold and Crohn’s disease are similar in that the patient experiences a marked increase in body temperature and abnormal thermoregulation, which causes the body temperature to exceed the normal level. Both fevers may cause different symptoms such as low or high fever after the attack, and high fever needs to be cooled down in time to avoid prolonged high body temperature which may cause damage to the central nervous system. However, the specific pathogenesis of fever caused by colds and Crohn’s disease is not the same. Fever caused by colds is mostly a common complication of viral or bacterial infections or autoimmune deficiency, which can be effectively relieved by timely administration of antimicrobial drugs and fever-reducing medications. On the other hand, fever caused by Crohn’s disease needs to be considered as intestinal aseptic inflammation, secondary bacterial infection or endocrine disease, etc. Therefore, it is necessary to choose the appropriate medication according to the specific cause of the disease. After the fever symptoms, it is recommended to go to the hospital in time for routine blood and biochemical examination, which can determine the specific cause of the disease, so as to choose the appropriate drugs under the guidance of the doctor.