The claim that a one-minute solution to leg cramps lacks some scientific basis. Leg cramps may be related to hypocalcemia, varicose veins in the legs, venous thrombosis in the lower extremities, etc., and need to be treated with medication, physical therapy, and surgery. For leg cramps due to high neuromuscular excitability caused by hypocalcemia, intravenous calcium chloride and other calcium supplements, oral calcium gluconate and other calcium supplements, vitamin D such as calcitriol, etc. can be given as prescribed by the doctor. For leg cramps due to ischemia caused by varicose veins in the legs, radiofrequency treatment can be performed under the operation of the doctor to relieve ischemia in the legs and improve the symptoms of leg cramps, or consider vein ligation. For leg cramps caused by lower extremity venous thrombosis and leg ischemia, the application of anticoagulants such as warfarin and thrombolytic drugs such as urokinase can be prescribed by the doctor; if the medication is not effective, venous thrombectomy can be considered. Therefore, it is recommended that people with leg cramps go to a regular hospital in a timely manner, to clarify the cause of the disease, standardized treatment under the guidance of the doctor, and not blindly believe in the solution under the guidance of non-professionals, so as not to delay the condition of the body to bring about adverse effects to the body to increase the additional burden on the body, not to mention blindly use medication.