Some patients who have been taking rabeprazole for 10 years may experience adverse effects. After long-term continuous use, patients may experience a series of adverse reactions such as osteoporosis, electrolyte disorders, anemia, malnutrition, gastritis, and gastric polyps. 1. Osteoporosis: long-term use of rabeprazole is prone to osteoporosis, and even prone to fractures. 2. Electrolyte disorders: long-term use of electrolyte metabolic disorders, especially hypomagnesemia. 3. Nutritional anemia: it is easy to make the body lack of absorption of some nutrients, such as iron, vitamin B₁₂, etc., inducing nutritional anemia, such as iron deficiency anemia, megaloblastic anemia. 4. Gastritis: long-term use can cause atrophic gastritis. 5. Gastric polyps: gastric fundic gland polyps may also occur, the specific mechanism is not known. Rabeprazole in the process of taking a variety of adverse reactions may occur, the above adverse reactions are mentioned in the instructions, the specific use of drugs should be under the guidance of a doctor.