Chronic stone-free cholecystitis pain that is not relieved by medication may be caused by physiologic factors such as eating fried chicken, or by pathologic factors such as enterogenic bacterial infection and gallbladder ischemia. It can be relieved and treated with a light diet, abdominal massage, and drugs such as indomethacin. 1. Physiological factors: Consumption of cold, greasy, spicy and stimulating foods such as fried chicken, beer, spicy hot pot, ice cream, etc. can cause increased bile secretion, resulting in abdominal pain, nausea, vomiting and other symptoms. It can be relieved by eating a light diet, avoiding the intake of alcohol and other stimulating foods, as well as localized massage in the abdomen. 2. Pathologic factors: (1) Bacterial infection of intestinal origin: intestinal bacteria such as Escherichia coli can retrograde to the gallbladder through the bile ducts, or reach the gallbladder through the blood or lymphatic pathway, causing abdominal pain and other symptoms, which can be treated by taking broad-spectrum antibacterial drugs such as cefixime and levofloxacin for anti-infection. (2) Gallbladder ischemia: sepsis, shock, severe trauma, etc. can lead to ischemia and local inflammatory reaction and necrosis of the gallbladder mucosa, etc., which can be treated by taking non-steroidal anti-inflammatory drugs such as indomethacin and celecoxib. Chronic stone-free cholecystitis pain is not relieved after taking medication, it is recommended to consult a doctor to clarify the diagnosis, under the guidance of the doctor for targeted treatment.