The inner thigh long lumps feel hard and painless, if it is a hard chancre, you should choose penicillin drug treatment in time; if it is a cyst or lipoma can be surgically treated; if it is a normal lymph node inflammation, you need to choose a sensitive antibiotic treatment. 1. chancre: mainly due to syphilis spirochete infection caused by sexually transmitted diseases, the first stage of syphilis will lead to chancre, manifested in the genitals or around the skin, there is a texture of the skin like cartilage like hard knots, may lead to the inner thighs long pimples feel hard and painless, should be diagnosed through the intramuscular injection, or intravenous penicillin class drug treatment in a timely manner. 2. Cysts or lipomas: sebaceous cysts, epidermal cysts, or lipomas and other diseases can also lead to thigh pimples feel hard and painless, usually need to take surgical resection and other methods of treatment. 3. lymphadenitis: inguinal lymphadenitis, early may also be manifested in the inner thigh pimples feel hard and painless, you can take cefadroxil, ofloxacin and other antibiotics treatment. The inner thigh pimples feel hard and painless, there may be other reasons, it is recommended to go to the hospital in a timely manner to clarify the cause of the disease, and follow the doctor’s instructions for treatment. All of the above drugs should be used in accordance with the doctor’s instructions, do not self-medication.