The way in which high creatinine can be brought down depends largely on the cause of the elevation. If the cause is physiological, it can be improved by removing the influencing factors and usually does not need special treatment. If the cause is pathologic, such as acute kidney injury, chronic renal insufficiency, etc., it is necessary to correct the cause of the disease in time, and if necessary, give medication, dialysis treatment, surgical treatment and so on. 1. Physiological reasons: some patients’ elevated blood creatinine may be caused by their high muscle content, or eating more meat and exercising more, if there is no abnormality in routine urinalysis and ultrasound of urinary system, creatinine may return to normal after adjusting the lifestyle, and no special treatment is needed at this time. 2. Pathologic factors: (1) Acute kidney injury: pre-renal causes such as insufficient effective blood volume, reduced cardiac output, etc., post-renal causes such as prostate hypertrophy, tumor, etc., can make creatinine high, can actively remove the causes of the disease, such as rehydration and dilation, removal of obstruction, etc., which can make creatinine drop lower and return to normal. (2) Chronic renal insufficiency: such as glomerulonephritis, hypertensive renal damage, etc., active treatment of underlying diseases, preferred ACEI or ARB drugs such as captopril, valsartan, etc., oral urethane, Haikun renal Xie and other drugs in order to detoxify the body, dialysis treatment when necessary, conditions permitting the feasibility of renal transplantation surgery. All of the above medications should be used under the guidance of a doctor, avoid self-medication. If patients find that the blood creatinine is elevated, it is recommended to go to the regular hospital in time, under the guidance of doctors to standardize the treatment.