Acne with hard bumps, i.e. nodules and cysts formed in the later stages of inflammatory acne, can be improved by topical medications and oral medications. 1. Topical medications: Antibacterial preparations such as benzoyl peroxide, clindamycin and metronidazole can be used to reduce the colonization of Propionibacterium acnes on the face and alleviate acne symptoms. At the same time, topical retinoic acid preparations, such as retinoic acid ointment, adapalene, etc., can dissolve acne and regulate the keratinization of the follicular opening. 2. Oral medication: If the inflammation of facial acne is severe, oral tetracycline antibiotics can be used to fight infection, such as doxycycline, minocycline, etc. After the inflammation improves, oral isotretinoin can regulate the keratinization and reduce acne. The above medications should be taken under the guidance of a physician. If the symptoms are severe, go to the hospital in time.