The advantages and disadvantages of neoadjuvant chemotherapy before surgery after puncture biopsy of breast cancer are as follows: Advantages: neoadjuvant for breast cancer can make the tumor size smaller and the stage lower, so that the inoperable can be operated and the non-breast-conserving can be breast-conserving; at the same time, it can determine the sensitivity of the tumor to the drugs and guide the follow-up medication, and those who are sensitive are suggested to have a better prognosis, and those who are not sensitive need postoperative intensive treatment to improve the prognosis. Disadvantage: If the adverse reaction of chemotherapy occurs after neoadjuvant chemotherapy, it may affect the follow-up treatment of patients. For the case of insensitive neoadjuvant chemotherapy, instead of achieving the expected effect of neoadjuvant chemotherapy, the patient loses the opportunity of surgical treatment and has a poor prognosis. Of course, there are specific indications for neoadjuvant therapy for breast cancer. It is recommended that patients receive standardized treatment under the guidance of professional doctors and in combination with their own conditions.