Hand blistering and peeling need to be based on the specific disease medication, may be sweat herpes, tinea cruris, palmoplantar impetigo, etc., commonly used glucocorticoid drugs, calcium-modulated phosphatase inhibitors, antifungal drugs, etc.,. 1. Sweat herpes: this is a special type of hand eczema, which can be treated with topical glucocorticoid ointment, such as tretinoin, mometasone furoate cream, or calcium-modulated phosphatase inhibitors such as tacrolimus ointment and pimecrolimus cream. 2. Ringworm: ringworm is caused by dermatophytes infecting the skin of the hands, mainly using antifungal drugs, such as clotrimazole cream, ketoconazole cream, etc. If the symptoms are serious, you can also take oral antifungal drugs, such as terbinafine, itraconazole. 3. palmoplantar pustulosis: palmoplantar pustulosis is aseptic pustules on the palms of the hands or soles of the feet, there will be skin flaking after the pustules subside, mainly the use of glucocorticoid drugs, such as hydrocortisone cream, dexamethasone cream, etc., and at the same time, you can apply Vitamin A acid ointment. Hand blisters peeling should go to the hospital, clear cause, symptomatic use of drugs, the above medication should be used under the guidance of a doctor, avoid self-medication.