We cannot analyze whether the patient’s condition is serious only from the positive anti-SSA antibody, but we have to make a comprehensive analysis from the causes of the positive anti-SSA antibody, the patient’s condition and personal situation, etc. Positive anti-SSA antibody is mainly seen in dry syndrome, systemic lupus erythematosus and other diseases. Anti-SSA antibody is a kind of autoantibody, which is firstly found in patients with dry syndrome. Under normal circumstances, anti-SSA antibody should be negative, and the positive result is mainly seen in autoimmune diseases, such as primary dry syndrome, rheumatoid arthritis, systemic lupus erythematosus, primary biliary cholangitis, systemic sclerosis, polymyositis, etc. In addition to this, anti-SSA antibody is mainly seen in patients with dry syndrome and systemic lupus erythematosus. In addition, positive anti-SSA antibody can also be seen in chronic active hepatitis, so patients with positive antibody test results should further improve the blood sedimentation, CRP, autoantibodies and other ancillary tests to determine the cause of the disease and to rule out laboratory errors, most autoimmune diseases can not be cured, and need long-term maintenance treatment, after early, standardized treatment can control the patient’s disease progression. Laboratory test results should be interpreted by a professional physician, and it is recommended that patients with positive anti-SSA antibodies go to the Department of Rheumatology and Immunology of a regular hospital for detailed consultation.