Patients diagnosed with gallstones with acute cholecystitis need to actively cooperate with the doctor’s treatment, and common treatments include general auxiliary therapeutic measures, drug treatment and surgical treatment. 1. When the diagnosis of gallstones with acute cholecystitis is confirmed, general auxiliary therapeutic measures, such as fasting, gastrointestinal decompression, fluid infusion and other treatments should be carried out immediately before other treatments. 2. Drug treatment includes the use of anti-infective drugs and analgesics, anti-infective drugs can choose ceftazidime, cefoperazone, cefazoxime and metronidazole, ornidazole, tinidazole and so on, and analgesics can choose diclofenac sodium capsules, tramadol hydrochloride tablets and so on. 3. When drug treatment is ineffective, timely surgical treatment should be carried out, such as laparoscopic cholecystectomy. It is recommended that the patient go to the hospital, improve the examination, under the guidance of the doctor for treatment.