It is not necessary to have a liver puncture to find out the cause of high transaminases. Transaminases usually refer to alanine aminotransferase and glutamine aminotransferase, which are mainly found in liver cells, but also in cardiomyocytes, skeletal muscle cells and other tissues, therefore, when cardiomyocytes (e.g. myocardial infarction, etc.), skeletal muscle cells (e.g. dermatomyositis, etc.) and other tissues are diseased, the enzyme will also be elevated. Therefore, when the cause of high aminotransferase cannot be found, it is not necessarily a liver lesion, and liver puncture is not necessary. Other systemic diseases, such as cardiovascular system, skeletal muscle system, etc., should be considered, and cardiac enzymes, muscle magnetic resonance imaging and other tests should be perfected in order to make a clear diagnosis. High aminotransferase needs to consult the doctor in time, and improve the relevant examinations to make a clear diagnosis, so as to avoid delaying the condition.