General numbness after chemotherapy for stage IV colon cancer is generally considered to be caused by neurotoxicity after chemotherapy, such as mild numbness can be considered to be treated with symptomatic nutritive nerve therapy, while severe cases can be considered to reduce the dose of chemotherapy or even stop the drug. Commonly used chemotherapeutic drugs for colon cancer, such as oxaliplatin, have peripheral neurotoxicity in clinical application, which is often manifested as sensory abnormalities of limbs and skin, such as coldness and numbness, especially when touching metal and alternating hot and cold, which is more obvious. When oxaliplatin is applied, mild numbness, without special treatment. In severe cases, sensory hypersensitivity, pain and other manifestations, if necessary, need to reduce the amount of chemotherapeutic drugs or change the drug treatment.