Anti-sperm antibody is mainly caused by the contact between the sperm and the immune system of the body, and after the corresponding condition occurs, it will affect the survival rate of the sperm as well as the conception status, and the first choice of treatment is isolation therapy. The preferred treatment is isolation therapy, i.e., the use of condoms during intercourse to isolate the sperm from the female body and further reduce the production of anti-sperm antibodies. It is generally recommended that the diaphragm be used for 6 months. A small portion of the effect is not obvious can be under the guidance of the doctor with small doses of oral corticosteroids to inhibit the immune response, such as prednisolone, dexamethasone, methylprednisolone, etc., usually need to be taken for more than 3 months. Anti-sperm antibody positive has been unsuccessful in preparation for pregnancy, the need for timely medical observation, diagnosis of the condition in the clinician under the guidance of standardized treatment, to avoid delays in the condition.