Lowly differentiated adenocarcinoma in gallbladder cancer invades the whole layer, indicating that the cancer cells have infiltrated and spread to the periphery, it is better to have timely surgery and adjuvant radiotherapy, as well as active supportive treatment. Gallbladder cancer refers to malignant tumors occurring in gallbladder (including gallbladder base, body, neck and gallbladder duct), and the proportion of those originating from gallbladder base, body and neck are 60%, 30% and 10% respectively. Its treatment mainly includes: 1. Surgery: Early gallbladder cancer can be cured by cholecystectomy; however, in middle and late stages, the chance of radical surgery is often lost, and it is necessary to expand the scope of resection and combine with the resection of surrounding organs/tissues; and patients with advanced stages usually can only receive palliative surgery. 2. Chemotherapy: chemotherapy can prolong the survival of unresectable gallbladder cancer. Currently, gemcitabine combined with cisplatin regimen is the standard first-line chemotherapy for unresectable gallbladder cancer; gemcitabine combined with Tegretol regimen can also be chosen. 3. Radiotherapy: it is suitable for the high-risk recurrence groups such as radical resection of gallbladder cancer with T2 stage or above, positive margins or positive lymph nodes, patients after palliative surgical treatment of gallbladder cancer and tumor recurrence, as well as patients who cannot be operated. 4. In patients with unresectable or recurrent gallbladder cancer, if there is a high degree of microsatellite instability or a lack of cell mismatch repair mechanism, they can be treated with the immune checkpoint inhibitors karelizumab or navumab. It is recommended to go to regular hospitals for consultation and treatment, and cooperate with the treatment as prescribed by the doctor, so as to avoid delaying the condition.