Patients with intermediate and advanced intrahepatic cholangiocarcinoma have a wide range of tumors, which are difficult to be eradicated. Generally, diversified treatments are adopted, i.e., surgery for those who can be operated, and conservative treatment for those who cannot be operated. 1. Surgery: For middle and advanced intrahepatic cholangiocarcinoma patients who can be operated or can be operated after neoadjuvant therapy, surgery should be performed as far as possible to resect the lesion, and then supplemented with molecular targeting and other treatments. 2. Conservative treatment: For completely inoperable intrahepatic cholangiocarcinoma patients in the middle and advanced stages, most of the tumors have already metastasized and can not be eradicated, so conservative treatments, such as chemotherapy, radiotherapy, molecular targeting and so on, are usually adopted. At this time, doctors will take measures to improve jaundice and gastrointestinal obstruction, control the patient’s condition and alleviate the patient’s symptoms. Chemotherapy drugs include gemcitabine, cisplatin, etc., and molecular targeted drugs include sorafenib, etc., and the use of drugs should be carried out under medical advice. At the same time, note that during the patient’s treatment, health care workers and family members should let the patient maintain an optimistic mindset, supplement the body with more nutrition, and eat small meals of easily digestible light food.