If there is more bleeding in the middle of taking Tranquilizer, i.e. Estradiol Valerate Tablet, the cause of bleeding needs to be clarified before corresponding measures can be taken. Estradiol valerate tablets is a kind of estrogen drug, during the period of taking the drug, the occurrence of drug withdrawal bleeding is normal, usually due to insufficient dose of the drug or the endometrium is thicker, etc. If the amount of bleeding is more, you can continue to take the drug first, and if the bleeding can not be stopped after taking the drug, then consider taking hemostatic drugs in order to stop the bleeding. If the bleeding is still heavy after taking medication to stop bleeding, it may be caused by pelvic inflammatory disease, uterine fibroids and other gynecological diseases, and it is necessary to go to the hospital to do ultrasound, sex hormones and other related tests to clarify the cause, and then under the guidance of the doctor for treatment of the disease. Hormonal drugs should be taken in strict accordance with the doctor’s instructions, and should not be discontinued or the dosage changed without authorization during the period of taking estradiol valerate tablets, and if there is any discomfort, consult the doctor in time.