Kawasaki disease rash is one of the early manifestations of the disease and needs to be treated for the disease itself, often with medications such as aspirin and gammaglobulin. Kawasaki disease is an acute systemic vasculitis disease that occurs in children and infants. Common clinical manifestations include fever, conjunctival congestion, strawberry tongue, etc. Skin manifestations include erythema multiforme and scarlet fever-like rash. Commonly used drugs, such as aspirin, can provide anti-inflammatory effects when used in full dosage in the early stages of the disease, and small-dose maintenance use can prevent thrombosis. Early high-dose titration of gammaglobulin can effectively improve symptoms and shorten the course of the disease. The disease has a certain degree of self-limitation, most of the prognosis is good, it is recommended to follow the doctor’s instructions to standardize the use of medication, can reduce the chances of complication of coronary artery disease.