For the itchy symptoms of hand, foot and mouth disease, can be used externally with glycerine lotion to stop itching, if necessary, with oral cetirizine and other antihistamines. 1. Hand, foot and mouth disease is mainly caused by enteroviruses, with Coxsackie virus A16 and enterovirus 71 being the most common. For as well as the appearance of herpes can be used glycerine lotion on the hands, feet, buttocks and other places to apply, in order to reduce the symptoms of itching. If herpes is broken, fusidic acid cream and mupirocin ointment can be used to prevent infection. 2. If the itching is more obvious, you can also take oral cetirizine, loratadine and other antihistamines to relieve itching; at the same time, pay attention to trim the patient’s nails to avoid scratching the herpes, otherwise it will cause infection and aggravate the itching. All of the above drugs need to be used under the guidance of a doctor, it is recommended that timely to the hospital, follow the doctor’s instructions standardized treatment.