There are many reasons for coughing at 12 p.m., commonly found in cough variant asthma, gastroesophageal reflux disease, cardiac insufficiency, chronic pharyngitis and so on. 1. Cough variant asthma: a special type of asthma, mainly characterized by irritating dry cough, mostly at night and early morning episodes, without obvious wheezing, shortness of breath and other symptoms. It can cause 12 o’clock cough. 2. Gastroesophageal reflux disease (GERD): a chronic disease in which the contents of the stomach and duodenum reflux into the esophagus, resulting in a series of symptoms. Sleeping in a flat state, acidic reflux may reflux into the throat, irritating the throat and trachea, causing coughing, pharyngeal discomfort and other symptoms. Its can cause 12 points cough. 3. cardiac insufficiency: a part of patients with chronic cardiac insufficiency, lying down at night will appear to increase the volume of return blood, heart load increases, aggravate the lungs bruises, causing coughing, accompanied by dyspnea, coughing up pink foamy sputum, need to consult a doctor in a timely manner. 3. Chronic pharyngitis: chronic pharyngitis can also cause coughing during sleep at night, because the vagus nerve excitation at night will lead to diaphragmatic spasm, aggravate coughing symptoms, the pharynx and respiratory mucous membranes in the case of long-term open-mouth breathing, long-term stimulation by cold air, causing airway spasm and coughing. There are many reasons for coughing at 12 o’clock at night, it is recommended to go to the hospital in time, to clarify the cause of the disease, under the guidance of the doctor for treatment.