The difference between bivalent HPV vaccine and quadrivalent HPV vaccine lies in the different types of viruses and different immunization procedures. 1. Different virus types: bivalent HPV vaccine can be used to prevent HPV types 16 and 18, while quadrivalent HPV vaccine can be used to prevent HPV types 6, 11, 16 and 18. bivalent HPV vaccine can prevent about 70% of cervical cancers, and quadrivalent HPV vaccine can prevent about 70% of cervical cancers and about 90% of genital warts. 2. Immunization procedures are different: bivalent HPV vaccine is normally administered at the 0th, 1st and 6th month, respectively, for a total of 3 doses. If you are a 9 to 14 year old female, you can also choose to receive 1 dose at the 0th and 6th month respectively, a total of 2 doses. Quadrivalent HPV vaccine is usually given as 1 dose at months 0, 2 and 6, for a total of 3 doses.