Blisters on the palate broke pain is usually due to periodontal abscess, oral ulcers, herpes on the lips and mouth, etc. Periodontal abscess can be treated with penicillin and other medications and surgical treatment, oral ulcers can be treated with povidone-iodine and other medications and physical therapy, herpes on the lips and mouth can be treated with penciclovir and other medications. 1. periodontal abscess: periodontal abscess generally refers to the occurrence of pus in the periodontal pocket by the pus discharge obstruction caused by the limited inflammation, there may be gum edema, tooth loosening and other symptoms, may also trigger the palate blisters broken pain symptoms, you can use metronidazole, tinidazole, penicillin and other medications, generally antibacterial effect, drug allergy is prohibited, but also to take periodontal flip flap surgery, abscess resection surgery, etc. Surgery. Treatment. 2. Oral ulcers: oral ulcers usually refers to the oral mucosal diseases caused by infection, mucosal damage and other factors, generally cause ulcers at the pain, redness, swelling and other symptoms, but also may cause blisters on the palate broke the symptoms of pain, you can use isacridine, chlorhexidine, polyvidone iodine and other drugs, generally anti-inflammatory effect, drug allergy is prohibited, but also can take microwave therapy instrument irradiation, laser and other physical therapy. The medicines are generally anti-inflammatory, and are contraindicated in case of drug allergy. 3. Oral and lip herpes: oral and lip herpes is generally referred to by viral infections, low immunity and other skin diseases, patients usually appear local skin itching, burning and other symptoms, but also may cause the palate blistering broken pain symptoms, you can use vasiclovir, acyclovir, penciclovir, and other medications, generally has an antiviral effect, drug allergy is prohibited. Patients should seek timely medical attention and early formal treatment. Drugs should be used under the guidance of a physician.