The appearance of blisters on the skin of the heel may be due to eczema, friction of shoes and socks, etc. Interventions can be made through medication and changing shoes and socks. Blisters on the heel due to eczema or other causes are usually scattered or clustered small blisters with severe itching. Skin blisters caused by shoe or sock discomfort are usually less itchy and may be accompanied by pain. For blisters caused by tinea pedis, eczema, etc., medication is needed. Medication is mainly based on topical medications such as hydrocortisone cream, trimethoprim acetate cream, etc. If the symptoms are severe, oral loratadine, cetirizine and other medications can be used for intervention. For blisters caused by wear and tear of shoes and socks, it is recommended to change comfortable shoes and socks to avoid further wear and tear. In addition, if there is a combination of ruptured blisters, topical disinfection such as iodophor can be used to avoid infection. For blisters on the heel, if the blisters are small and itchy, it is recommended to go to the hospital and get a clear understanding of the cause of the blisters and treat them under the guidance of the doctor.