Fever in a 10-year-old child for no apparent reason may be related to pathogenic microbial infections, systemic lupus erythematosus, and other factors, and it is critical to address the cause of the illness while providing antipyretic treatment. For children with fever but body temperature <38.5 ℃ can use warm water on the forehead, reduce the clothing worn and other physical methods to reduce temperature, encourage children to drink more water, some children's body temperature can gradually decline, for children with body temperature ≥38.5 ℃ need to use antipyretic drugs such as ibuprofen, acetaminophen and other antipyretic treatments under the guidance of a doctor. At the same time for the cause of the treatment is also very important for the recovery of body temperature. 1. Pathogenic microorganisms infection: common pathogens are virus, bacteria, mycoplasma, etc., which may affect the respiratory tract or digestive tract, and then may show the symptoms of fever, there is no special medication for viral infections; for bacterial infections, we can use antibiotics such as ceftazidime according to the results of drug sensitivity; for mycoplasma infections, we can use azithromycin and other medications. 2. Systemic lupus erythematosus (SLE): it is an autoimmune disease that invades the connective tissues of the whole body of multiple systems and organs, and it may also have the symptom of fever. In the acute stage, bed rest should be provided, nutrition should be strengthened, and sun exposure should be avoided; ibuprofen, hydroxychloroquine sulfate, cyclophosphamide, azathioprine and methotrexate can be used for treatment according to the doctor's instruction. All of the above medications should be used under the guidance of a doctor, avoiding self-medication.There are many other causes of fever in 10 year olds, and it is recommended that they be seen promptly and evaluated by a specialist.