Nail melanoma is a malignant tumor originated from melanocytes with high degree of malignancy, and the harm is mainly affecting the life expectancy, affecting the aesthetics, and striking the self-confidence. 1. Hazardous to life: melanoma of nails progresses quickly, often increases in size in a short period of time, and the survival rate of patients with ulcers and metastases is low. 2. Affecting aesthetics: melanoma lesions on the extremities show uneven pigmentation, irregular border patches, which can be longitudinal banded pigment stripes, and melanoma growing on the nails often attracts other people’s attention and affects patients’ self-confidence. Extremity freckle melanoma is a common type of melanoma in China, which mostly develops from limb freckle nevus, therefore, when hemorrhoids appear on limbs for no reason, we should be alert, and we should seek medical treatment in time for those diagnosed with melanoma, and choose the appropriate treatment under the guidance of professional doctors, so as to maximize the quality of life.