Acid reflux and heartburn after meals are usually caused by chronic gastritis or gastroesophageal reflux disease, etc. It is necessary to clarify the cause of the disease and then treat the symptoms, including medication, general treatment and so on. Patients with chronic gastritis mostly exhibit chronic periodic rhythmic abdominal pain, which may also be accompanied by abdominal pain after a full meal and acid reflux heartburn. For chronic gastritis caused by Hp (Helicobacter pylori) infection requires radical Hp treatment, including a proton pump inhibitor such as omeprazole, a bismuth agent such as bismuth potassium citrate, 2 antimicrobial drugs such as clarithromycin, metronidazole, etc., and the course of treatment is mostly 10 to 14 days. Gastroesophageal reflux disease if the patient manifests acid reflux, heartburn, and accompanied by warmth, retrosternal pain and other manifestations. It is recommended that patients go to the hospital in time to do gastroscopy, after the doctor’s diagnosis to take acid-suppressing drugs such as omeprazole, ranitidine, etc., or take to promote gastrointestinal dynamics of drugs such as domperidone treatment. Acid reflux heartburn after meals can also be seen in peptic ulcers, especially gastric ulcers, so it is recommended that patients with any discomfort timely consultation, under the guidance of a professional doctor to actively treat, to avoid delaying the condition. Drugs should be used in accordance with medical advice.