Itchy blisters on the soles of the feet are considered to be caused by tinea pedis, herpes sweat, external friction, etc. They can be treated by applying and taking oral medication. 1. Tinea pedis: Tinea pedis is caused by fungal infection, caused by dermatophytes invading the stratum corneum of the skin and causing infection, which can be manifested as small blisters on the feet, accompanied by itching. You can apply ketoconazole cream or solution and other antifungal preparations, but also oral antifungal drugs such as terbinafine, etc.; secondary infection requires oral antibiotics. 2. Sweat herpes: it occurs in the heart of the foot and the lateral edge of the toes, is deep in the small blisters, dry and flaky, with itching, burning sensation. Glucocorticoid creams such as hydrocortisone cream can be used externally, and when itching is obvious, antihistamine drugs can be taken orally, such as cetirizine hydrochloride tablets, loratadine tablets and so on. 3. External friction: usually wear inappropriate shoes or walk for too long, repeatedly rubbing the local skin, blisters with itching in the center of the foot. You need to wear suitable shoes and avoid walking for too long; the blisters can be absorbed by yourself when they are small, and when they are big, you can go to the hospital to absorb the blisters with the help of the doctor. Itchy blisters on the soles of the feet may also be caused by insect bite dermatitis, erythema multiforme, etc. It is recommended to go to the hospital in time to clarify the cause of the disease and follow the doctor’s instructions for treatment.